Two goals by Paraguay striker Oscar Cardozo helped Benfica to a 4-0 win over Hertha Berlin on Tuesday to clinch a place in the last 16 of the Europa League.
Fellow Serie A sides Atalanta and Lazio also won while Portugal's Vitoria Guimaraes began their match against Salzburg with not a single European player in the team.
Burnley reached the Europa League third qualifying round with a 3-1 win over Aberdeen after extra time at Turf Moor on Thursday but now face another tough battle to increase their squad size.
Javier Zanetti made his 800th appearance for Inter Milan in the Italians' 2-0 win at Romania's Vaslui in a Europa League tie on Thursday.
A stunning late goal from Benfica's Lima left Juventus's hopes of reaching a home Europa League final hanging in the balance after a 2-1 first-leg defeat, while Sevilla won 2-0 against Valencia in Thursday's all-Spanish last-four clash.
Chelsea led a trio of English clubs into the Europa League quarter-finals on Thursday after Tottenham Hotspur survived a thrilling Inter Milan fightback to advance on away goals and Newcastle United got a late winner.
Images from Friday's Premier League matches between Chelsea and Manchester United, Aston Villa and Tottenham Hotspur.
The return fixtures will be played on May 11 and the final in Stockholm on May 24.
Eden Hazard scored twice and created a third to steer Chelsea to a 4-1 victory over London rivals Arsenal in the Europa League final in what looks likely to be the Belgium winger's final game for the Blues.
Napoli went down 3-1 at home to RB Leipzig, Arsenal and AC Milan enjoyed comfortable away wins, and Borussia Dortmund's Michy Batshuayi scored twice to secure a 3-2 victory in Europa League last 32, first leg action
Mario Gomez dusted off his shooting boots to put Fiorentina in the driving seat with a 1-1 Europa League draw at Juventus while Benfica were too good for Tottenham Hotspur, winning their last-16 first leg 3-1 away on Thursday.
Jonatan Soriano's love affair with the Europa League continued as last season's top scorer grabbed a hat-trick on Thursday to help Salzburg become one of four teams to reach the knockout stages.
A Romelu Lukaku hat-trick in a 4-1 win for Everton at Young Boys and a thrilling 3-3 draw between Celtic and Inter Milan.
'We've crammed in weeks of what you'd normally do into five days, so you know, we have asked a lot, but the first half was a long way short from where we want to be physically.'
Manchester United's season, already their worst in the Premier League, hit a new low with their 1-0 defeat to Spurs in that final in Bilbao that denied them a spot in this season's Champions League.
Yet Milan's defensive frailty was punished when Konstantinos Fortounis scored from the penalty spot in the 81st minute to give his side the win that left them second in Group F on 10 points.
Sevilla stayed firmly on course for a second consecutive Europa League crown when an Aleix Vidal double and a Kevin Gameiro strike secured a thumping 3-0 win at home to Fiorentina in their semi-final first leg on Thursday.
AS Roma secured their place in the Europa League last 16 with a 3-2 home win over 10-man Porto on Thursday thanks to a Paulo Dybala double, advancing 4-3 on aggregate.
Rashford scores a brace as Man United fight back to beat Omonia
Ajax Amsterdam produced a performance worthy of the club's illustrious past when they crushed Olympique Lyonnais 4-1 on Wednesday to move to the brink of their first European final since 1996.
Liverpool draw Sparta Prague in Europa League last 16
Atletico Madrid striker Diego Costa haunted Arsenal again by firing his side to a 1-0 win in Thursday's Europa League semi-final second leg to send the Spaniards into the final and deny Arsene Wenger a dream end to his long reign as Arsenal coach.
IMAGES from Europa League matches played on Thursday.
Former Europa League winners Manchester United booked a quarter-final spot in the tournament after their second-string side laboured to a 2-1 home win over LASK Linz on Wednesday to seal a 7-1 aggregate rout of the Austrian side.
Benfica kept alive their dream of a first European trophy in 52 years after a goalless draw with Juventus in Turin on Thursday helped the newly-crowned Portuguese champions win their Europa League semi-final 2-1 on aggregate.
Valencia turned the tables on a stunned Basel side to reach the Europa League semi-finals on Thursday with a 5-0 win after extra time thanks to a Paco Alcacer hat-trick as they recovered from a three-goal first-leg deficit.
Arsenal had scored 10 goals in two matches against BATE Borisov in the same competition in 2017 but never looked like being as prolific in the freezing temperatures of Belarus.
Troubled AC Milan were held to a goalless draw by AEK Athens
London sides Tottenham Hotspur and Arsenal made winning starts as did fellow Premier League club Leicester City.
Man United boss Amorim says he has no plans to quit
Tottenham Hotspur's Erik Lamela scored a stunning 'rabona' goal to light up Thursday's Europa League ties, wrapping his left boot round the back of his right leg 20 metres out and blasting the ball into the top corner.
Ajax to face United in final despite defeat at Lyon
Arsenal led a list of nine clubs who grabbed a second win in as many games in the Europa League group phase as France striker Olivier Giroud scored his 100th goal for the club in a 4-2 win at BATE Borisov on Thursday.
Manchester United's Paul Pogba and Henrikh Mkhitaryan scored a goal in each half as their team comfortably outclassed Ajax Amsterdam to win an emotional Europa League final 2-0 and qualify for the group stages of the Champions League.
Andrea Pirlo kept Juventus on course for a home Europa League final after his superb free kick settled their battle with Italian rivals Fiorentina to send the Serie A leaders into the quarter-finals on Thursday.
Thirteen teams have now qualified for the last 32 including Bayer Leverkusen, FC Zurich and Lazio who had already secured places in the next stage of the competition.
Managerless Tottenham Hotspur face a long trip to Ukraine for a meeting with former boss Juande Ramos after being drawn against Dnipro Dnipropetrovsk in the last 32 of the Europa League.
Bilbao condemn fans behaviour in Europa League match at Roma
Bruno Fernandes milestone and late drama lift Manchester United past Chelsea with a chaotic 2-1 win over Chelsea at Old Trafford